anti-CD45 BC8 monoclonal antibody-streptavidin conjugate

{
  "id": "MLC-T-ONC-010396",
  "term": "anti-CD45 BC8 monoclonal antibody-streptavidin conjugate",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate containing a monoclonal antibody directed against the CD45 antigen BC8, conjugated to streptavidin, a nonglycosylated homotetrameric protein that has four high affinity binding sites for biotin. Anti-CD45 BC8 antibody-streptavidin conjugate binds to CD45, a transmembrane protein tyrosine phosphatase that is expressed on the surface of normal and malignant hematopoietic cells. Upon administration of a biotin-based radioconjugate, the biotin moiety of the radioconjugate binds to the streptavidin moiety of anti-CD45 BC8 antibody-streptavidin conjugate and, upon cellular internalization, specifically delivers cytotoxic radiation to CD45-expressing tumor cells.",
  "abbreviation": "BC8-SA",
  "synonyms": [
    "BC8 scFv4SA fusion protein",
    "anti-CD45 BC8 antibody-streptavidin fusion protein",
    "anti-CD45 monoclonal antibody BC8-streptavidin conjugate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd45-bc8-monoclonal-antibody-streptavidin-conjugate/"
}