astatine At 211 anti-CD45 monoclonal antibody BC8-B10

{
  "id": "MLC-T-ONC-011259",
  "term": "astatine At 211 anti-CD45 monoclonal antibody BC8-B10",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MAb) BC8 where the lysine side groups have been conjugated with decaborate (closo-decaborate; B10) and labeled with astatine (At) 211, with potential immunotherapeutic activity. Astatine At 211 anti-CD45 monoclonal antibody BC8-B10 binds to CD45 antigen, a receptor protein-tyrosine phosphatase expressed on the surface of both normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, this agent may deliver a cytotoxic dose of alpha radiation. Additionally, the radiolabel can be leveraged to assay the biodistribution and/or pharmacokinetics (absorption, distribution, metabolism and excretion) for this agent. The use of B10 rather than other labeling methods increases the therapeutic efficacy while decreasing the toxicity of the radioconjugate.",
  "abbreviation": "At 211 MAb BC8-B10",
  "synonyms": [
    "astatine 211-labeled anti-CD45 monoclonal antibody BC8-B10",
    "astatine At 211 MAb BC8-B10",
    "At 211 anti-CD45 monoclonal antibody BC8-B10"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/astatine-at-211-anti-cd45-monoclonal-antibody-bc8-b10/"
}