yttrium Y 90 anti-CD45 monoclonal antibody BC8

{
  "id": "MLC-T-ONC-017623",
  "term": "yttrium Y 90 anti-CD45 monoclonal antibody BC8",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb) BC8 labeled with yttrium 90 (Y90), with potential immunotherapeutic activity. Yttrium Y 90 anti-CD45 monoclonal antibody BC8 binds to CD45 antigen, a receptor protein-tyrosine phosphatase expressed on the surface of both normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, this agent may deliver a cytotoxic dose of beta radiation.",
  "abbreviation": "90Y anti-CD45 MAb BC8",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/yttrium-y-90-anti-cd45-monoclonal-antibody-bc8/"
}