astatine At 211 anti-CD38 monoclonal antibody OKT10-B10

{
  "id": "MLC-T-ONC-011258",
  "term": "astatine At 211 anti-CD38 monoclonal antibody OKT10-B10",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of the anti-CD38 monoclonal antibody (MoAb) OKT10-B10 labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 anti-CD38 MoAb OKT10-B10, the MoAb moiety targets and binds to CD38-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein and tumor-associated antigen (TAA), is present on various immune cells and in hematologic malignancies; its expression has been correlated with poor prognosis.",
  "synonyms": [
    "astatine 211-labeled anti-CD38 monoclonal antibody OKT10-B10",
    "At211-OKT10-B10",
    "astatine-211-OKT10-B10",
    "211At-OKT10-B10",
    "[211At]OKT10-B10",
    "astatine At 211 anti-CD38 MoAb OKT10-B10"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/astatine-at-211-anti-cd38-monoclonal-antibody-okt10-b10/"
}