Astatine At 211 F(ab')2 MX35

{
  "id": "MLC-T-ONC-011260",
  "term": "Astatine At 211 F(ab')2 MX35",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of the F(ab')2 fragment of monoclonal antibody MX35 targeting the sodium-dependent phosphate transport protein 2b (NaPi2b; SLC34A2) labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 F(ab')2 MX35, the F(ab')2 MX35 moiety targets and binds to NaPi2b-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the NaPi2b-expressing tumor cells. NaPi2b, a multi-transmembrane, sodium-dependent phosphate transporter, is highly expressed in certain types of tumor cells.",
  "synonyms": [
    "At211-MX35 F(ab')2",
    "astatine At 211-MX35 F(ab')2",
    "211-astatine-MX35 F(ab')2",
    "211 At astatine-labeled MX35 F(ab')2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/astatine-at-211-f-ab-2-mx35/"
}