anti-EGFR/c-MET/c-MET trispecific antibody GB263T

{
  "id": "MLC-T-ONC-010608",
  "term": "anti-EGFR/c-MET/c-MET trispecific antibody GB263T",
  "field": "Oncology and biomedicine",
  "definition": "A Fc-enhanced trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-met trispecific antibody GB263T simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes on c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and inducing internalization of EGFR and c-Met. This downregulates the expression levels of both EGFR and c-Met proteins and prevents the activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.",
  "synonyms": [
    "trispecific EGFR/cMET/cMET antibody GB263T",
    "EGFR x cMET x cMET trispecific antibody GB263T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-c-met-c-met-trispecific-antibody-gb263t/"
}