anti-EGFR/c-Met/c-Met trispecific antibody BG-T187

{
  "id": "MLC-T-ONC-010607",
  "term": "anti-EGFR/c-Met/c-Met trispecific antibody BG-T187",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-Met trispecific antibody BG-T187 simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes of c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.",
  "synonyms": [
    "anti-EGFR x c-MET x c-MET trispecific antibody BG-T187",
    "EGFR x cMET x cMET trispecific antibody BG-T187",
    "EGFR x MET TsAb BG-T187",
    "EGFR/cMET/cMET trispecific antibody BG-T187",
    "EGFRxMET trispecific antibody BG-T187"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-c-met-c-met-trispecific-antibody-bg-t187/"
}