anti-EGFR/c-Met bispecific antibody CKD-702

{
  "id": "MLC-T-ONC-010605",
  "term": "anti-EGFR/c-Met bispecific antibody CKD-702",
  "field": "Oncology and biomedicine",
  "definition": "A tetravalent, bispecific antibody composed of a single-chain variable fragment (scFv) targeting epidermal growth factor receptor (EGFR) fused to the c-terminus of an immunoglobulin G1 (IgG1) antibody targeting hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met bispecific antibody CKD-702 simultaneously targets and binds to the extracellular domains of wild-type or certain mutant forms of both EGFR and c-Met expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and c-Met-mediated signaling pathways. In addition, binding results in receptor degradation, which further inhibits EGFR- and c-Met-mediated signaling, thereby inhibiting tumor cell proliferation. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.",
  "synonyms": [
    "anti-EGFR/anti-c-Met bispecific antibody CKD-702",
    "EGFR x c-Met bispecific antibody CKD-702"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-c-met-bispecific-antibody-ckd-702/"
}