anti-human cytomegalovirus monoclonal antibody combination CSJ-148

{
  "id": "MLC-T-ONC-010800",
  "term": "anti-human cytomegalovirus monoclonal antibody combination CSJ-148",
  "field": "Oncology and biomedicine",
  "definition": "A combination agent composed of two human monoclonal antibodies against the human cytomegalovirus (HCMV), LJP538 and LJP539, with potential immunomodulating activity. Upon administration of CSJ-148, both LJP538 and LJP539 bind to and inhibit the function of viral HCMV glycoproteins that are essential for HCMV infection; LJP538 targets and binds to glycoprotein B (gB) and LJP539 targets and inhibits the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients.",
  "synonyms": [
    "antiviral agent CSJ148",
    "HCMV neutralizing human mAb combination CSJ-148"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-human-cytomegalovirus-monoclonal-antibody-combination-csj-148/"
}