Antifungal agent VL-2397

{
  "id": "MLC-T-ONC-010676",
  "term": "Antifungal agent VL-2397",
  "field": "Oncology and biomedicine",
  "definition": "A cyclic hexapeptide and natural compound isolated from the Malaysian leaf litter fungus, Acremonium persicinium MF-347833, with potential antifungal activity against various invasive fungal infections including invasive aspergillosis (IA). Upon administration, VL-2397, by resembling the siderophore ferrichrome, is specifically taken up by fungal cells through the membrane-bound transporter siderophore iron transporter 1 (Sit; Sit1). Upon fungal cell entry, VL-2397 targets and binds to an as of yet undisclosed intracellular site, thereby killing fungal cells. Since mammalian cells lack the Sit1 transporter, VL-2397 is not taken up by human cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/antifungal-agent-vl-2397/"
}