autologous anti-CDH17 CAR-T cells CHM-2101

{
  "id": "MLC-T-ONC-011411",
  "term": "autologous anti-CDH17 CAR-T cells CHM-2101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cadherin-17 (CDH17), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-CDH17 CAR-T cells CHM-2101 are reintroduced into the patient and are directed to tumor cells expressing CDH17, which may result in a selective toxicity against, and lysis of CDH17-expressing tumor cells. CDH17, a cell surface adhesion protein, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "autologous anti-cadherin-17 CAR-T cells CHM-2101",
    "autologous anti-CDH17 CAR T cells CHM-2101",
    "CDH17 CAR T cells CHM-2101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cdh17-car-t-cells-chm-2101/"
}