autologous dendritic cells pulsed with MART-1 (26-35) peptide

{
  "id": "MLC-T-ONC-011605",
  "term": "autologous dendritic cells pulsed with MART-1 (26-35) peptide",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based vaccine consisting of autologous HLA-A2*0201-restricted dendritic cells (DC), which were derived from patient-harvested adherent peripheral blood monocytes cultured in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), that were pulsed with a peptide fragment comprised of amino acid residues 26 through 35 of melanoma antigen recognized by T cells 1 (MART-1 (26-35)), with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination, autologous DC pulsed with MART-1 (26-35) peptide may stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1. MART-1, a protein involved in melanosome biogenesis, is overexpressed by melanoma cells. The MART-1 (26-35) peptide is highly immunogenic for the HLA-A2*0201 haplotype.",
  "synonyms": [
    "autologous MART-1 (26-35) peptide pulsed DC vaccine",
    "autologous MART-1 (26-35) peptide pulsed dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-dendritic-cells-pulsed-with-mart-1-26-35-peptide/"
}