CD16/IL15/CD33 trispecific killer cell engager OXS-3550

{
  "id": "MLC-T-ONC-012370",
  "term": "CD16/IL15/CD33 trispecific killer cell engager OXS-3550",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific killer engager (TriKE) molecule containing an anti-cluster of differentiation 16 (CD16; FcgammaRIII) single-chain variable fragment (scFv) to engage natural killer (NK) cells, an anti-CD33 scFv to engage myeloid cells and a human modified interleukin-15 (IL-15) linker, that links the two scFv, with potential immunomodulating and antineoplastic activities against CD33-expressing tumor cells. Upon administration of the CD16/IL15/CD33 TriKE OXS-3550, the simultaneous binding to CD16 on NK cells and CD33 on tumor cells will induce NK cell cytotoxicity specifically against CD33-expressing tumor cells. The cytokine IL-15 linker promotes NK cell proliferation, activity, survival and expansion. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells.",
  "synonyms": [
    "CD16/IL15/CD33 TriKE",
    "CD16/IL-15/CD33 161533 tri-specific killer engagers",
    "161533 TRIKE",
    "CD16/IL15/CD33 TriKE OXS-3550"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd16-il15-cd33-trispecific-killer-cell-engager-oxs-3550/"
}