anti-CD16/IL-15/anti-CD33 trispecific natural Killer cell engager GTB-3650

{
  "id": "MLC-T-ONC-010247",
  "term": "anti-CD16/IL-15/anti-CD33 trispecific natural Killer cell engager GTB-3650",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific natural killer (NK) cell engager comprised of an anti-cluster of differentiation 16 (CD16; FcgammaRIII) camelid nanobody, human interleukin-15 (IL-15), and an anti-CD33 single-chain variable fragment (scFv), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD16/IL-15/anti-CD33 trispecific NK cell engager GTB-3650 targets and binds to CD33 expressed on tumor cells and simultaneously binds to the activating CD16 Fc receptor expressed on NK cells, thereby bringing CD33-expressing tumor cells and NK cells together. This induces NK cell cytotoxicity specifically against CD33-expressing tumor cells. The cytokine IL-15 promotes NK cell proliferation, activity, survival and expansion. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells.",
  "synonyms": [
    "anti-CD16/IL-15/anti-CD33 trispecific killer engager GTB-3650",
    "anti-CD16/IL-15/anti-CD33 trispecific NK cell engager GTB-3650",
    "anti-CD16/IL-15/anti-CD33 trispecific NK engager GTB-3650",
    "anti-CD16/IL15/anti-CD33 TriKE GTB-3650"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd16-il-15-anti-cd33-trispecific-natural-killer-cell-engager-gtb-3650/"
}