chloroquinoxaline sulfonamide

{
  "id": "MLC-T-ONC-001692",
  "term": "chloroquinoxaline sulfonamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called CQS.",
    "A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner."
  ],
  "abbreviation": "CQS",
  "synonyms": [
    "CQS",
    "chlorsulfaquinoxaline",
    "chlorosulfaquinoxaline"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/chloroquinoxaline-sulfonamide/"
}