Diaziquone

{
  "id": "MLC-T-ONC-002426",
  "term": "Diaziquone",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system. Also called AZQ.",
    "A synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks. Due to its lipophilicity, diaziquone readily crosses the blood brain barrier."
  ],
  "abbreviation": "AZQ",
  "synonyms": [
    "AZQ",
    "aziridinylbenzoquinone",
    "Aziridinyl Benzoquinone",
    "Aziridinylbenzoquinone carbamic acid"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/diaziquone/"
}