fluorine F 18 WC-4-116

{
  "id": "MLC-T-ONC-013701",
  "term": "fluorine F 18 WC-4-116",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of an isatin sulfonamide analog labeled with the positron-emitting isotope fluorine F 18, with potential imaging activity for activated caspase-3, which is a marker for apoptosis, using positron emission tomography/computed tomography (PET/CT). Upon administration, fluorine F 18 WC-4-116 is preferentially taken up by and accumulates in cells with high caspase-3 activity. Upon PET/CT imaging, caspase-3 activation may be detected, and apoptotic activity, including chemotherapy-induced tumor apoptosis, may be assessed. Caspase-3, a cysteine protease, plays an important role in apoptosis.",
  "synonyms": [
    "18F-FAT",
    "18F-fluorapo trace",
    "[18F]WC-4-116"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-wc-4-116/"
}