gene-edited autologous neoantigen-targeted NeoTCR-P1 T cells

{
  "id": "MLC-T-ONC-013928",
  "term": "gene-edited autologous neoantigen-targeted NeoTCR-P1 T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4- and CD8-positive T lymphocytes that have been engineered with site-specific nucleases to suppress the expression of most endogenous forms of the T-cell receptor (TCR) and promote expression of a single, native TCR targeting a neoepitope that is presented on the surface of a patient's tumor cells, with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the gene-edited autologous neoantigen-targeted NeoTCR-P1 T cells recognize and bind to tumor cells expressing the targeted neoantigen, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.",
  "synonyms": [
    "NeoTCR-P1",
    "NeoTCR-P1 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gene-edited-autologous-neoantigen-targeted-neotcr-p1-t-cells/"
}