Hsp70-peptide TKD/IL-2-activated autologous natural killer cells

{
  "id": "MLC-T-ONC-014199",
  "term": "Hsp70-peptide TKD/IL-2-activated autologous natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells.",
  "synonyms": [
    "Hsp70-peptide TKD/IL-2-activated autologous NK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hsp70-peptide-tkd-il-2-activated-autologous-natural-killer-cells/"
}