Recombinant 70-kD heat-shock protein

{
  "id": "MLC-T-ONC-016383",
  "term": "Recombinant 70-kD heat-shock protein",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response.",
  "abbreviation": "HSP70",
  "synonyms": [
    "70-kD Heat-Shock Protein",
    "Heat Shock Protein 70"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-70-kd-heat-shock-protein/"
}