Iodine I 124 omburtamab

{
  "id": "MLC-T-ONC-014512",
  "term": "Iodine I 124 omburtamab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of the iodine I 124-radiolabeled murine IgG1 monoclonal antibody omburtamab directed against the cell surface glycoprotein CD276 (4Ig-B7-H3) with potential for radioimaging using positron emission tomography (PET). Through convection enhanced delivery of iodine I 124 omburtamab, the antibody moiety binds to the 4Ig domain of CD276, and in turn CD276-expressing tumor cells may be visualized upon PET imaging of the iodine I 124 moiety. CD276, a tumor-associated antigen (TAA) and member of the B7 family of co-stimulatory proteins, suppresses natural killer (NK) cell and cytotoxic T-lymphocyte activation; it is expressed on the cell membranes of a wide variety of tumors of neuroectodermal, mesenchymal and epithelial origin and its expression is associated with increased aggressiveness, poor prognosis and resistance.",
  "abbreviation": "124I-8H9",
  "synonyms": [
    "iodine I 124 MOAB 8H9"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-124-omburtamab/"
}