recombinant human interleukin-22 IgG2-Fc

{
  "id": "MLC-T-ONC-016422",
  "term": "recombinant human interleukin-22 IgG2-Fc",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant fusion protein consisting of human cytokine interleukin 22 (IL-22) fused to a human immunoglobulin G2 (IgG2)-Fc, with potential cell protective activity. Upon intravenous administration of recombinant human IL-22 IgG2-Fc, IL-22 binds to its cognate receptor IL-22R, which is highly expressed in parenchymal tissues and epithelial cells at mucosal surfaces. This leads to the activation of IL-22/IL-22R-mediated signal transduction pathways, and results in the activation of signal transducer and activator of transcription 3 (STAT3). STAT3 activation may have a protective and regenerative effect and may protect against the development of various inflammatory and immunological diseases. Specifically, recombinant human IL-22 IgG2-Fc may protect intestinal stem cells from dying due to acute graft-versus-host disease (aGvHD). IL-22, produced by various immune cells and upregulated during inflammation, plays a key role in controlling immune responses and bacterial infection, and in the enhancement of intestinal barrier function, gut immunity, and tissue repair.",
  "synonyms": [
    "IL-22 IgG2-Fc",
    "recombinant human IL-22 IgG2-Fc",
    "IL-22 dimer F-652"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-human-interleukin-22-igg2-fc/"
}