ROBO1-targeted BiCAR-NKT cells

{
  "id": "MLC-T-ONC-016572",
  "term": "ROBO1-targeted BiCAR-NKT cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of natural killer T (NKT) cells engineered to express a chimeric antigen receptor (CAR) specific for roundabout homolog 1 (ROBO1, Robo1), with potential immunostimulating and antineoplastic activities. Upon administration, the ROBO1-targeted BiCAR-NK/T cells target and bind to ROBO1 expressed on the surface of tumor cells. This induces selective toxicity in ROBO1-expressing tumor cells. ROBO1, a member of the axon guidance receptor family, is often overexpressed in a variety of tumor types. It is involved in axon guidance, cell proliferation, cell motility and angiogenesis.",
  "synonyms": [
    "anti-ROBO1 BiCAR-NK/T cells",
    "ROBO1 CAR-NK/T cells",
    "ROBO1-targeted Bi-CAR-NK/T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/robo1-targeted-bicar-nkt-cells/"
}