salt-inducible kinase inhibitor GRN-300

{
  "id": "MLC-T-ONC-016628",
  "term": "salt-inducible kinase inhibitor GRN-300",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule inhibitor of the salt inducible kinases 2 (SIK2) and 3 (SIK3), with potential antineoplastic activity. Upon oral administration of SIK inhibitor GRN-300, this agent targets, binds to and blocks the activity of SIK2 and SIK3. This prevents SIK2/3-mediated signaling, blocks centrosome separation, and inhibits proliferation in SIK2/3-overexpressing tumor cells. GRN-300 may enhance tumor sensitivity to other chemotherapeutic agents. SIK2/3, serine/threonine centrosome kinase family members required for bipolar mitotic spindle formation, are overexpressed in a variety of tumor cell types.",
  "synonyms": [
    "ARN3261",
    "SIK inhibitor GRN-300"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/salt-inducible-kinase-inhibitor-grn-300/"
}