Adverse Effect

{
  "id": "MLC-T-ENV-000606",
  "term": "Adverse Effect",
  "field": "Environment",
  "definition": "1. A biochemical change, functional impairment, or pathologic lesion that affects the performance of the whole organism, or reduces an organism's ability to respond to an additional environmental challenge.\n\n2. Any effect that causes harm to the normal functioning of plants or animals due due to exposure to a substance (i.e., a chemical contaminant).\n\n3. A biochemical change, functional impairment, or pathological lesion that either singly or in combination adversely affects the performance of the whole organism or reduces an organism's ability to respond to an additional environmental challenge.\n\n4. (Adverse ecological effects) Changes considered undesirable because they alter valued structural or functional characteristics of ecosystems or their components.\n\n5. Any deleterious effect to organisms due to exposure to a substance. This includes effects which are or may become debilitating, harmful or toxic to the normal functions of the organism, but does not include non-harmful effects such as tissue discoloration alone or the induction of enzymes involved in the metabolism of the substance. [40 CFR 132.2 (CFR 2013)]\n\n6. Change in morphology, physiology, growth, development, or life span of an organism that results in impairment of functional capacity or impairment of capacity to compensate for additional stress or increase in susceptibility to the harmful effects of other environmental influences. Decisions on whether or not any effect is adverse require expert judgment. [WHO 1994]\n\n7. Change in the morphology, physiology, growth, development, reproduction or life span of an organism, system, or (sub) population that results in an impairment of functional capacity, an impairment of the capacity to compensate for additional stress, or an increase in susceptibility to other influences. [IPCS/OECD 2004]\n\n8. A biochemical change, functional impairment, or pathologic lesion that affects the performance of the whole organism, or reduces an organism’s ability to respond to an additional environmental challenge. [EPA 2003]\n\n9. Change in morphology, physiology, growth, development or lifespan of an organism that results in impairment of functional capacity or impairment of capacity to compensate for additional stress or increase in susceptibility to the harmful effects of other environmental influences. [ILSI 2001]",
  "subject": "Science and research",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Ecological Risk Assessment Glossary of Terms",
    "Benchmark Dose Software (BMDS) Glossary of Terms",
    "EPA 1998a",
    "40 CFR Appendix C to Part 132 (CFR 2013)",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/adverse-effect/"
}