Developmental Toxicity

{
  "id": "MLC-T-ENV-007847",
  "term": "Developmental Toxicity",
  "field": "Environment",
  "definition": "1. Adverse effects on the developing organism that may result from exposure prior to conception (either parent), during prenatal development, or postnatally until the time of sexual maturation. The major manifestations of developmental toxicity include death of the developing organism, structural abnormality, altered growth, and functional deficiency.\n\n2. Adverse effects on the developing organism that may result from exposure prior to conception or postnatally to the time of sexual maturation. Adverse developmental effects may be detected at any point in the life span of the organism. Major manifestations of developmental toxicity include death of the developing organism; induction of structural abnormalities (teratogenicity); altered growth; and functional deficiency.\n\n3. The potential of an agent to cause abnormal development. Developmental toxicity generally occurs in a dose-related manner, may result from short-term exposure (including single exposure situations) or from longer term low-level exposure, may be produced by various routes of exposure, and the types of effects may vary depending on the timing of exposure because of a number of critical periods of development for various organs and functional systems. The four major manifestations of developmental toxicity are death, structural abnormality, altered growth, and functional deficit.\n\n4. Adverse effects on the developing organism that may result from exposure prior to conception (either parent), during prenatal development, or postnatally until the time of sexual maturation. The major manifestations of developmental toxicity include death of the developing organism, structural abnormality, altered growth, and functional deficiency. [EPA 2003]\n\n5. The potential of an agent to cause abnormal development. Developmental toxicity generally occurs in a dose-related manner, may result from short-term exposure (including single exposure situations) or from longer term low-level exposure, may be produced by various routes of exposure, and the types of effects may vary depending on the timing of exposure because of a number of critical periods of development for various organs and functional systems. The four major manifestations of developmental toxicity are death, structural abnormality, altered growth, and functional deficit. [EPA 2004]",
  "subject": "Science and research",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Benchmark Dose Software (BMDS) Glossary of Terms",
    "EPA 2004",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/developmental-toxicity/"
}