[18F]-labeled substance P antagonist receptor quantifier

{
  "id": "MLC-T-ONC-000028",
  "term": "[18F]-labeled substance P antagonist receptor quantifier",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radiolabeled substance being studied in PET imaging of the brain. It is also being studied as a way to find where cancer cells have spread in patients with pancreatic cancer. It binds to cell receptors for substance P, also known as neurokinin-1, which is found on nerve cells and on some types of cancer cells, such as pancreatic cancer cells. [18F]-labeled substance P antagonist receptor quantifier is a type of PET radioligand and a type of radiolabeled neurokinin-1 receptor antagonist.",
    "A radioconjugate consisting of the positron emitting radioisotope fluorine F 18 conjugated to the substance P antagonist receptor quantifier (SPA-RQ) used in radioimaging. [18F]-labeled substance P antagonist receptor quantifier is an antagonist of the neurokinin 1 (substance P) receptor (NK1R) and can function as a positron emission tomography (PET) imaging agent for detecting NK1R-expressing cells and tissues. NK1Rs are frequently expressed on the plasma membranes of tumor cells from glioblastoma and breast and pancreatic carcinomas."
  ],
  "abbreviation": "[18F]SPA-RQ",
  "synonyms": [
    "(18F)-L-829165",
    "L-829165 F-18"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/18f-labeled-substance-p-antagonist-receptor-quantifier/"
}