anti-TROP2-CAR-IL-15-transduced Cord blood-derived natural killer cells

{
  "id": "MLC-T-ONC-011161",
  "term": "anti-TROP2-CAR-IL-15-transduced Cord blood-derived natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TROP2-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.",
  "synonyms": [
    "anti-TROP2-CAR-IL-15-expressing CB-NK cells",
    "anti-TROP2-CAR-IL-15-transduced CB-derived NK cells",
    "anti-TROP2CAR/IL15-transduced CB-NK cells",
    "TROP2-CAR-engineered IL15-transduced cord blood-derived NKs",
    "TROP2-CAR-IL-15 CBNKs",
    "TROP2-CAR/IL15-transduced CBNK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-trop2-car-il-15-transduced-cord-blood-derived-natural-killer-cells/"
}