allogeneic anti-CD70-CAR-IL-15-transduced cord blood-derived natural killer cells

{
  "id": "MLC-T-ONC-009829",
  "term": "allogeneic anti-CD70-CAR-IL-15-transduced cord blood-derived natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells.",
  "synonyms": [
    "allogeneic anti-CD70-CAR-IL-15-expressing CB-NK cells",
    "allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells",
    "CAR.70-engineered IL15-transduced cord blood-derived NK cells",
    "CAR.70/IL15-transduced CB-NK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd70-car-il-15-transduced-cord-blood-derived-natural-killer/"
}