Allogeneic anti-NY-ESO-1-TCR-IL-15-transduced cord blood-derived natural killer cells

{
  "id": "MLC-T-ONC-009833",
  "term": "Allogeneic anti-NY-ESO-1-TCR-IL-15-transduced cord blood-derived natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human cancer-testis antigen NY-ESO-1 and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-NY-ESO-1-TCR-IL-15-transduced CB-derived NKs target, bind to and induce selective cytotoxicity in NY-ESO-1-expressing tumor cells. NY-ESO-1 is found in normal testis and on the surface of various tumor cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells.",
  "synonyms": [
    "allogeneic anti-NY-ESO-1 TCR-transduced IL-15-expressing CB-derived NK cells",
    "cord blood-derived NK cells genetically engineered with NY-ESO-1 TCR/IL-15 NKs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-ny-eso-1-tcr-il-15-transduced-cord-blood-derived-natural-killer/"
}