autologous anti-ALPP CAR retroviral vector-transduced T cells

{
  "id": "MLC-T-ONC-011325",
  "term": "autologous anti-ALPP CAR retroviral vector-transduced T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) targeting alkaline phosphatase, placental type (ALPP; placental alkaline phosphatase; PLAP), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-ALPP CAR retroviral vector-transduced T cells target and bind to ALPP-expressing tumor cells, thereby inducing selective toxicity in ALPP-expressing tumor cells. ALPP, mainly expressed in placenta and testis, is overexpressed on certain tumor cell types, such as on a proportion of colorectal cancers while not expressed in any other normal tissues. It plays a key role in tumor cell proliferation.",
  "synonyms": [
    "anti-ALPP CAR-expressing retroviral vector-transduced autologous T cells",
    "autologous anti-ALPP CAR T cells",
    "retroviral vector-transduced anti-PLAP CAR autologous T cells",
    "autologous anti-ALPP CAR-modified T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-alpp-car-retroviral-vector-transduced-t-cells/"
}