Autologous CD8+ SLC45A2-specific T lymphocytes

{
  "id": "MLC-T-ONC-011566",
  "term": "Autologous CD8+ SLC45A2-specific T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD8+ T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T lymphocytes (CTLs), the autologous CD8+ SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity.",
  "synonyms": [
    "autologous SLC45A2-specific cytotoxic T lymphocytes",
    "autologous SLC45A2-specific CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd8-plus-slc45a2-specific-t-lymphocytes/"
}