autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T lymphocytes

{
  "id": "MLC-T-ONC-011656",
  "term": "autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) fused to a human immunoglobulin G1 (IgG1) hinge and a CD8alpha transmembrane domain, linked to the co-stimulatory molecule 4-1BB (CD137) and the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), containing the apoptosis-inducible suicide gene human caspase 9 (iCASP9 or iC9), linked to a drug binding domain, and a truncated low-affinity nerve growth factor receptor (deltaNGFR), with potential immunostimulating and antineoplastic activities. The iC9 construct consists of the sequence of the human FK506-binding protein (FKBP12) with an F36V mutation, connected through a Ser-Gly-Gly-Gly-Ser linker to the gene-encoding human caspase 9, which is deleted of its endogenous caspase activation and recruitment domain. Upon transfusion, the iCasp9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes target and bind to CD19-expressing neoplastic B cells. Prior to administration, deltaNGFR is used to select the CAR19-transduced T cells for further enrichment by flow cytometry using an anti-NGFR antibody.",
  "synonyms": [
    "iCasp9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing autologous T lymphocytes",
    "autologous iC9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing T cells",
    "iCasp9-deltaNGFR-CD19CAR-CD3zeta-4-1BB-expressing autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-ic9-deltangfr-cd19car-cd3zeta-4-1bb-expressing-t-lymphocytes/"
}