Flortaucipir F-18

{
  "id": "MLC-T-ONC-013622",
  "term": "Flortaucipir F-18",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer disease (AD) and chemotherapy-induced cognitive impairment (CICI).",
  "synonyms": [
    "18F-AV-1451",
    "[18F]T807",
    "F 18 T807",
    "[F18]T807",
    "fluorine F18 T807",
    "fluorine-18-labeled 7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flortaucipir-f-18/"
}