meta-fluorine F 18 fluorobenzylguanidine

{
  "id": "MLC-T-ONC-015116",
  "term": "meta-fluorine F 18 fluorobenzylguanidine",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the positron-emitting radioisotope fluorine F 18 labeled benzylguanidine, a synthetic analogue of the adrenergic neurotransmitter norepinephrine (NE), with potential use in the diagnostic imaging of human norepinephrine transporter (hNET)-expressing cells by either positron emitting tomography (PET) or computed tomography (CT). Upon administration, meta-fluorine F 18 fluorobenzylguanidine (MFBG) is taken up by and accumulates in both the granules of adrenal medullary chromaffin cells and the pre-synaptic granules of adrenergic neurons in a manner almost identical to that of NE. In turn, hNET-expressing tumor cells can be imaged by PET or CT. hNET, a transmembrane protein and regulator of catecholamine uptake normally restricted to the central and peripheral sympathetic nervous system, is overexpressed in certain tumor cell types.",
  "abbreviation": "18F-MFBG",
  "synonyms": [
    "meta-[(18)F]-fluorobenzylguanidine",
    "18F meta-fluoro benzylguanidine",
    "meta-fluoro benzylguanidine F-18"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/meta-fluorine-f-18-fluorobenzylguanidine/"
}