monoclonal antibody Lym-1

{
  "id": "MLC-T-ONC-015267",
  "term": "monoclonal antibody Lym-1",
  "field": "Oncology and biomedicine",
  "definition": "A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils.",
  "abbreviation": "MOAB Lym-1",
  "synonyms": [
    "IgG2a murine monoclonal antibody Lym-1",
    "Lym-1",
    "monoclonal antibody Lym-1, IgG2a murine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/monoclonal-antibody-lym-1/"
}