pDNA-encoding Emm55 autologous cancer cell vaccine IFx-Hu2.0

{
  "id": "MLC-T-ONC-015895",
  "term": "pDNA-encoding Emm55 autologous cancer cell vaccine IFx-Hu2.0",
  "field": "Oncology and biomedicine",
  "definition": "A whole cell cancer vaccine composed of irradiated autologous whole tumor cells that are transfected, ex vivo, with a plasmid DNA encoding the highly immunogenic Streptococcus pyogenes (S. pyogenes) bacterial antigen Emm55, with potential immunostimulating and antineoplastic activities. Upon intralesional administration of IFx-Hu2.0, the tumor cells expressing the Emm55 bacterial antigen on their cell surface are taken up and processed by antigen-presenting cells (APCs), thereby presenting both the Emm55 and the patient-specific tumor-associated antigens (TAAs) to the immune system. This activates the immune system to elicit a tumor antigen-specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the tumor cells expressing the TAAs.",
  "synonyms": [
    "plasmid DNA autologous cancer vaccine IFx-Hu2.0",
    "autologous cancer cell-transfected with plasmid DNA encoding for Emm55 Streptococcal antigen IFx-Hu2.0",
    "pDNA autologous cancer cell vaccine IFx-Hu2.0",
    "plasmid DNA vaccine encoding S. pyogenes Emm55 protein"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pdna-encoding-emm55-autologous-cancer-cell-vaccine-ifx-hu2-0/"
}