Hansch analysis

{
  "id": "MLC-T-CHM-005090",
  "term": "Hansch analysis",
  "field": "Chemistry",
  "definition": "A quantitative structure-activity method in which the biological potency of a series of related compounds is expressed as a regression equation in physicochemical descriptors, using the linear free-energy relationships of physical organic chemistry. Typical terms are the hydrophobic parameter π or log P, the Hammett electronic constant σ and a steric parameter such as Taft's Es. Corwin Hansch developed the approach in the 1960s.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 1997, 69, 1137. 'Glossary of terms used in computational drug design (IUPAC Recommendations 1997)' on page 1144 (https://doi.org/10.1351/pac199769051137)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hansch-analysis/"
}