Hansch constant

{
  "id": "MLC-T-CHM-005091",
  "term": "Hansch constant",
  "field": "Chemistry",
  "definition": "A parameter that quantifies the lipophilicity of a substituent in a molecule, derived from partition coefficients between an organic solvent (typically 1-octanol) and water. It is used in quantitative structure-activity relationships (QSAR) to correlate a molecule's structure with its biological activity. A positive value indicates greater lipophilicity, while a negative value suggests increased hydrophilicity.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "correlation analysis",
    "hydrophobic interaction",
    "lipophilic",
    "partition coefficient"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1119 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hansch-constant/"
}