Bilinear equation

{
  "id": "MLC-T-CHM-001217",
  "term": "Bilinear equation",
  "field": "Chemistry",
  "definition": "A non-linear QSAR equation, proposed by Kubinyi, that relates biological potency, expressed as log 1/C, to lipophilicity: log 1/C equals a log P minus b log(βP plus 1) plus c, where P is the partition coefficient and a, b, β and c are fitted constants. The curve rises linearly with log P, bends over and then falls linearly, which differs from the symmetric parabola of the Hansch equation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Hansch equation",
    "log P"
  ],
  "references": [
    "PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 242 (https://doi.org/10.1515/pac-2012-1204)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/bilinear-equation/"
}