Log D

{
  "id": "MLC-T-CHM-006748",
  "term": "Log D",
  "field": "Chemistry",
  "definition": "The logarithm of the distribution coefficient, which quantifies the ratio of the concentration of a compound in an organic phase to its concentration in an aqueous phase at a given pH. This value reflects the lipophilicity of an ionizable compound, accounting for both its neutral and ionized forms. It is a key parameter in drug discovery for predicting absorption, distribution, metabolism, and excretion properties.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 249 (https://doi.org/10.1515/pac-2012-1204)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/log-d/"
}