Heavy atom isotope effect

{
  "id": "MLC-T-CHM-005151",
  "term": "Heavy atom isotope effect",
  "field": "Chemistry",
  "definition": "A kinetic isotope effect observed when an atom heavier than hydrogen is substituted with one of its isotopes, leading to a change in reaction rate. This effect is typically smaller than primary hydrogen kinetic isotope effects but can still provide insights into the transition state structure. It arises from changes in vibrational frequencies due to the mass difference between isotopes.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "isotope effect",
    "isotopes"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1130 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/heavy-atom-isotope-effect/"
}