Inverse isotope effect

{
  "id": "MLC-T-CHM-006049",
  "term": "Inverse isotope effect",
  "field": "Chemistry",
  "definition": "A phenomenon where a reaction involving a heavier isotope proceeds faster than the same reaction involving a lighter isotope. This is contrary to the more common normal isotope effect, where reactions with lighter isotopes are faster due to lower zero-point energies. It typically arises when the force constants of the bonds involved in the rate-determining step change in a specific way upon isotopic substitution.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "force constants",
    "isotope effect",
    "kinetic isotope effect",
    "transition state"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1130 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/inverse-isotope-effect/"
}