Steric isotope effect

{
  "id": "MLC-T-CHM-011395",
  "term": "Steric isotope effect",
  "field": "Chemistry",
  "definition": "A change in the equilibrium constant or rate of a reaction when an atom is replaced by one of its isotopes, where the change is primarily due to differences in the effective size of the isotopes. This effect is typically small and arises from changes in vibrational amplitudes, which affect the average internuclear distances. It is a type of secondary isotope effect.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "equilibrium constant",
    "isotopologue",
    "secondary isotope effect",
    "steric effect"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1131 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/steric-isotope-effect/"
}