Lead optimisation

{
  "id": "MLC-T-CHM-006499",
  "term": "Lead optimisation",
  "field": "Chemistry",
  "definition": "The systematic process of modifying a lead compound to improve its potency, selectivity, pharmacokinetic properties, and reduce toxicity, thereby enhancing its drug-like characteristics. This stage involves iterative cycles of chemical synthesis, biological testing, and structural analysis. The goal is to transform a promising lead into a viable drug candidate for preclinical development.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1147 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lead-optimisation/"
}