Lethal synthesis

{
  "id": "MLC-T-CHM-006525",
  "term": "Lethal synthesis",
  "field": "Chemistry",
  "definition": "The biochemical conversion of a relatively harmless compound into a toxic metabolite within a living organism. This process often involves enzymatic reactions that transform the parent compound into a more reactive or biologically active form. An example is the conversion of fluoroacetate to fluorocitrate, which inhibits the Krebs cycle.",
  "synonyms": [
    "suicide metabolism"
  ],
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2063 (https://doi.org/10.1351/pac199365092003)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lethal-synthesis/"
}