Linkage analysis

{
  "id": "MLC-T-CHM-006647",
  "term": "Linkage analysis",
  "field": "Chemistry",
  "definition": "A genetic method used to map the location of genes on chromosomes by observing how frequently two genetic markers or a marker and a disease trait are inherited together. It relies on the principle that genes located physically close to each other on a chromosome are less likely to be separated by recombination during meiosis. The strength of linkage is quantified by the logarithm of the odds (LOD) score.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "LOD score"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 773 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/linkage-analysis/"
}