Local effect

{
  "id": "MLC-T-CHM-006733",
  "term": "Local effect",
  "field": "Chemistry",
  "definition": "A toxicological response that occurs at the site of contact between a chemical substance and an organism, without being absorbed into the systemic circulation. This effect is confined to the area of exposure, such as skin irritation from a corrosive agent. It contrasts with systemic effects, which manifest after absorption and distribution throughout the body.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1583. 'Explanatory dictionary of key terms in toxicology (IUPAC Recommendations 2007)' on page 1619 (https://doi.org/10.1351/pac200779091583)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/local-effect/"
}