First-pass effect

{
  "id": "MLC-T-CHM-004441",
  "term": "First-pass effect",
  "field": "Chemistry",
  "definition": "The biotransformation of a substance during its initial passage from the site of absorption into the systemic circulation. This process typically occurs in the liver for orally administered drugs, where enzymes metabolize the compound before it reaches its target. The first-pass effect significantly reduces the bioavailability of many therapeutic agents.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "biotransformation",
    "elimination",
    "systemic effect"
  ],
  "references": [
    "PAC, 2004, 76, 1033. 'Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)' on page 1052 (https://doi.org/10.1351/pac200476051033)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/first-pass-effect/"
}