Somatic hypermutation

{
  "id": "MLC-T-CHM-013570",
  "term": "Somatic hypermutation",
  "field": "Chemistry",
  "definition": "A cellular process that introduces point mutations into the variable regions of immunoglobulin genes in B lymphocytes, primarily within germinal centers. This process increases the diversity of antibody specificities, allowing for the production of antibodies with higher affinity for antigens. It is a key mechanism in the adaptive immune response.",
  "synonyms": [
    "mutation (in immunology)"
  ],
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 805 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/somatic-hypermutation/"
}